New potential binding determinant for hERG channel inhibitors

Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K(+) current (I(Kr)) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Saxena, P., Zangerl-Plessl, E.-M., Linder, T., Windisch, A., Hohaus, A., Timin, E., Hering, S., Stary-Weinzinger, A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828713/
https://ncbi.nlm.nih.gov/pubmed/27067805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24182
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker