New potential binding determinant for hERG channel inhibitors

Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K(+) current (I(Kr)) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants...

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Foilsithe in:Sci Rep
Main Authors: Saxena, P., Zangerl-Plessl, E.-M., Linder, T., Windisch, A., Hohaus, A., Timin, E., Hering, S., Stary-Weinzinger, A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828713/
https://ncbi.nlm.nih.gov/pubmed/27067805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24182
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