Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions

CD4 and CD8 T lymphocyte activation requires the generation of sufficient energy to support new biosynthetic demands. Following T cell receptor (TCR) engagement, these requirements are met by an increased glycolysis, due, at least in part, to induction of the Glut1 glucose transporter. As Glut1 is u...

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Udgivet i:Sci Rep
Main Authors: Cretenet, Gaspard, Clerc, Isabelle, Matias, Maria, Loisel, Severine, Craveiro, Marco, Oburoglu, Leal, Kinet, Sandrina, Mongellaz, Cédric, Dardalhon, Valérie, Taylor, Naomi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828702/
https://ncbi.nlm.nih.gov/pubmed/27067254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24129
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