Methotrexate induces differentiation of human keratinocytes.

Terminal differentiation is a key element in the maintenance of tissue homeostasis in the epidermis. We show here that methotrexate (MTX) induces differentiation of human epidermal keratinocytes in vitro. MTX inhibits proliferation of keratinocytes and also induces several markers of differentiation...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schwartz, P M, Barnett, S K, Atillasoy, E S, Milstone, L M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1731329/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.2.594
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