Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides

HLA-DM is essential for editing peptides bound to MHC class II, thus influencing the repertoire of peptides mediating selection and activation of CD4+ T cells. Individuals expressing HLA-DQ2 or DQ8, and DQ2/8 trans-dimers, have elevated risk for type 1 diabetes (T1D). Cells co-expressing DM with the...

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Bibliografiska uppgifter
I publikationen:Eur J Immunol
Huvudupphovsmän: Zhou, Zemin, Reyes-Vargas, Eduardo, Escobar, Hernando, Rudd, Brant, Rockwood, Alan L., Delgado, Julio C., He, Xiao, Jensen, Peter E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828309/
https://ncbi.nlm.nih.gov/pubmed/26707565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545942
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