Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice

Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of information on the optimal dose prohibits rationally designed trials assessing efficacy. To challenge the assumption that ‘more is better’ we compared the pharmacokinetics and activity of a dietary dose with an...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Scott, Edwina, Cai, Hong, Kholghi, Abeer, Andreadi, Catherine, Rufini, Alessandro, Karmokar, Ankur, Britton, Robert G., Horner-Glister, Emma, Greaves, Peter, Jawad, Dhafer, James, Mark, Howells, Lynne, Ognibene, Ted, Malfatti, Mike, Goldring, Christopher, Kitteringham, Neil, Walsh, Joanne, Viskaduraki, Maria, West, Kevin, Miller, Andrew, Hemingway, David, Steward, William P., Gescher, Andreas J., Brown, Karen
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827609/
https://ncbi.nlm.nih.gov/pubmed/26223300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa7619
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