Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

BACKGROUND: Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Abedalthagafi, Malak, Bi, Wenya Linda, Aizer, Ayal A., Merrill, Parker H., Brewster, Ryan, Agarwalla, Pankaj K., Listewnik, Marc L., Dias-Santagata, Dora, Thorner, Aaron R., Van Hummelen, Paul, Brastianos, Priscilla K., Reardon, David A., Wen, Patrick Y., Al-Mefty, Ossama, Ramkissoon, Shakti H., Folkerth, Rebecca D., Ligon, Keith L., Ligon, Azra H., Alexander, Brian M., Dunn, Ian F., Beroukhim, Rameen, Santagata, Sandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Basic and Translational Investigations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827048/
https://ncbi.nlm.nih.gov/pubmed/26826201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov316
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