Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

BACKGROUND: Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutat...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Abedalthagafi, Malak, Bi, Wenya Linda, Aizer, Ayal A., Merrill, Parker H., Brewster, Ryan, Agarwalla, Pankaj K., Listewnik, Marc L., Dias-Santagata, Dora, Thorner, Aaron R., Van Hummelen, Paul, Brastianos, Priscilla K., Reardon, David A., Wen, Patrick Y., Al-Mefty, Ossama, Ramkissoon, Shakti H., Folkerth, Rebecca D., Ligon, Keith L., Ligon, Azra H., Alexander, Brian M., Dunn, Ian F., Beroukhim, Rameen, Santagata, Sandro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827048/
https://ncbi.nlm.nih.gov/pubmed/26826201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov316
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