Treg depletion in non‐human primates using a novel diphtheria toxin‐based anti‐human CCR4 immunotoxin

Regulatory T cells (Treg) play an important role in modulating the immune response and has attracted increasing attention in diverse fields such as cancer treatment, transplantation and autoimmune diseases. CC chemokine receptor 4 (CCR4) is expressed on the majority of Tregs, especially on effector...

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Udgivet i:Mol Oncol
Main Authors: Wang, Zhaohui, Pratts, Shannon G., Zhang, Huiping, Spencer, Philip J., Yu, Ruichao, Tonsho, Makoto, Shah, Jigesh A., Tanabe, Tatsu, Powell, Harrison R., Huang, Christene A., Madsen, Joren C., Sachs, David H., Wang, Zhirui
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826841/
https://ncbi.nlm.nih.gov/pubmed/26643572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.11.008
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