Aldose Reductase acts as a Selective Derepressor of PPARγ and Retinoic Acid Receptor

Histone deacetylase 3 (HDAC3), a chromatin modifying enzyme, requires association with the deacetylase containing domain (DAD) of the nuclear receptor co-repressors NCOR1 and SMRT for its stability and activity. Here we show that aldose reductase (AR), the rate-limiting enzyme of the polyol pathway,...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Thiagarajan, Devi, Ananthakrishnan, Radha, Zhang, Jinghua, O’Shea, Karen M., Quadri, Nosirudeen, Li, Qing, Sas, Kelli, Jing, Xiao, Rosario, Rosa, Pennathur, Subramaniam, Schmidt, Ann Marie, Ramasamy, Ravichandran
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826833/
https://ncbi.nlm.nih.gov/pubmed/27052179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.086
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