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Smurf1 inhibits osteoblast differentiation, bone formation and glucose homeostasis through Serine 148
The E3 ubiquitin ligase Smurf1 targets the master regulator of osteoblast differentiation Runx2, for degradation yet the function of Smurf1 if any during osteoblast differentiation in vivo is ill-defined. Here we show that Smurf1 prevents osteoblast differentiation by decreasing Runx2 accumulation i...
Guardat en:
| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4826790/ https://ncbi.nlm.nih.gov/pubmed/27052174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.003 |
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