B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation

The function of B cells in osteoblast (OB) dysfunction in rheumatoid arthritis (RA) has not been well-studied. Here we show that B cells are enriched in the subchondral and endosteal bone marrow (BM) areas adjacent to osteocalcin(+) OBs in two murine RA models: collagen-induced arthritis and the TNF...

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Publicat a:Nat Commun
Autors principals: Sun, Wen, Meednu, Nida, Rosenberg, Alexander, Rangel-Moreno, Javier, Wang, Victor, Glanzman, Jason, Owen, Teresa, Zhou, Xichao, Zhang, Hengwei, Boyce, Brendan F., Anolik, Jennifer H., Xing, Lianping
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277442/
https://ncbi.nlm.nih.gov/pubmed/30510188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07626-8
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