Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node

Impaired immune effector functions in the melanoma sentinel lymph node (SLN) may allow for early metastatic events. In an effort to determine the optimal way to strengthen immune defenses, 28 clinical stage I–II melanoma patients were randomized in a 3-arm Phase II study to receive, prior to excisio...

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Détails bibliographiques
Publié dans:Cancer Immunol Immunother
Auteurs principaux: van den Hout, Mari F. C. M., Sluijter, Berbel J. R., Santegoets, Saskia J. A. M., van Leeuwen, Paul A. M., van den Tol, M. Petrousjka, van den Eertwegh, Alfons J. M., Scheper, Rik J., de Gruijl, Tanja D.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826413/
https://ncbi.nlm.nih.gov/pubmed/26935057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1811-z
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