T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A(+)CD141(+) cDC1 and CD14(+) antigen-presenting cell recruitment

BACKGROUND: We previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune activation of the sentinel lymph node (SLN), increased melanoma-specific CD8(+) T cell rates in peripheral blood, and prolonged recurrence-free surv...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Autores principales: Koster, Bas D, López González, Marta, van den Hout, Mari FCM, Turksma, Annelies W, Sluijter, Berbel JR, Molenkamp, Barbara G, van Leeuwen, Paul AM, Vosslamber, Saskia, Scheper, Rik J, van den Eertwegh, Alfons JM, van den Tol, M Petrousjka, Jordanova, Ekaterina J, de Gruijl, Tanja D
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978250/
https://ncbi.nlm.nih.gov/pubmed/33737341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001962
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