Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node

Impaired immune effector functions in the melanoma sentinel lymph node (SLN) may allow for early metastatic events. In an effort to determine the optimal way to strengthen immune defenses, 28 clinical stage I–II melanoma patients were randomized in a 3-arm Phase II study to receive, prior to excisio...

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Publicado en:Cancer Immunol Immunother
Autores principales: van den Hout, Mari F. C. M., Sluijter, Berbel J. R., Santegoets, Saskia J. A. M., van Leeuwen, Paul A. M., van den Tol, M. Petrousjka, van den Eertwegh, Alfons J. M., Scheper, Rik J., de Gruijl, Tanja D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826413/
https://ncbi.nlm.nih.gov/pubmed/26935057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1811-z
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