Neuron-targeted caveolin-1 improves molecular signaling, plasticity and behavior dependent on the hippocampus in adult and aged mice

BACKGROUND: Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by clustering pro-growth receptors and tethering cytoskeletal machinery necessary for neuronal sprouting. However, the effect of MLR and MLR-associated proteins on neuronal aging is unknown. ME...

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Publicat a:Biol Psychiatry
Autors principals: Mandyam, Chitra D., Schilling, Jan M., Cui, Weihua, Egawa, Junji, Niesman, Ingrid R., Kellerhals, Sarah E., Staples, Miranda C., Busija, Anna R., Risbrough, Victoria B., Posadas, Edmund, Grogman, Grace C., Chang, Jamie W., Roth, David M., Patel, Piyush M., Patel, Hemal H., Head, Brian P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826329/
https://ncbi.nlm.nih.gov/pubmed/26592463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.09.020
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