Neuron-targeted caveolin-1 improves molecular signaling, plasticity and behavior dependent on the hippocampus in adult and aged mice

BACKGROUND: Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by clustering pro-growth receptors and tethering cytoskeletal machinery necessary for neuronal sprouting. However, the effect of MLR and MLR-associated proteins on neuronal aging is unknown. ME...

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Gepubliceerd in:Biol Psychiatry
Hoofdauteurs: Mandyam, Chitra D., Schilling, Jan M., Cui, Weihua, Egawa, Junji, Niesman, Ingrid R., Kellerhals, Sarah E., Staples, Miranda C., Busija, Anna R., Risbrough, Victoria B., Posadas, Edmund, Grogman, Grace C., Chang, Jamie W., Roth, David M., Patel, Piyush M., Patel, Hemal H., Head, Brian P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826329/
https://ncbi.nlm.nih.gov/pubmed/26592463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.09.020
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