Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells

The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance and therapeutic potential of APC/C and its co-activator Cdc20 in multiple mye...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lub, Susanne, Maes, Anke, Maes, Ken, De Veirman, Kim, De Bruyne, Elke, Menu, Eline, Fostier, Karel, Kassambara, Alboukadel, Moreaux, Jérôme, Hose, Dirk, Leleu, Xavier, King, Randall W., Vanderkerken, Karin, Van Valckenborgh, Els
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826190/
https://ncbi.nlm.nih.gov/pubmed/26716651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6768
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