G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling

Mouse embryonic stem cells (mESCs) lack of G1 checkpoint despite that irradiation (IR) activates ATM/ATR-mediated DDR signaling pathway. The IR-induced p53 localizes in the nuclei and up-regulates p21/Waf1 transcription but that does not lead to accumulation of p21/Waf1 protein. The negative control...

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Gepubliceerd in:Cell Cycle
Hoofdauteurs: Suvorova, Irina I., Grigorash, Bogdan B., Chuykin, Ilya A., Pospelova, Tatiana V., Pospelov, Valery A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825740/
https://ncbi.nlm.nih.gov/pubmed/26636245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1120927
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