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G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling
Mouse embryonic stem cells (mESCs) lack of G1 checkpoint despite that irradiation (IR) activates ATM/ATR-mediated DDR signaling pathway. The IR-induced p53 localizes in the nuclei and up-regulates p21/Waf1 transcription but that does not lead to accumulation of p21/Waf1 protein. The negative control...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825740/ https://ncbi.nlm.nih.gov/pubmed/26636245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1120927 |
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