IL-12 induced the generation of IL-21- and IFN-γ-co-expressing poly-functional CD4+ T cells from human naive CD4+ T cells

Interleukine-12 is critical for the differentiation of Th1 cells and can improve the development of Th1 cells with Tfh cell features in mouse model. Human effector CD4(+) T cells also exhibit poly-functionality by co-expressing IL-21 and IFN-γ. However, the effects of IL-12 on regulating generation...

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Vydáno v:Cell Cycle
Hlavní autoři: Yu, Sifei, Jia, Lei, Zhang, Yannan, Zhong, Junmin, Yang, Binyan, Wu, Changyou
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825544/
https://ncbi.nlm.nih.gov/pubmed/26566861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1093703
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