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TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

IL-21 has pleiotropic effects on innate and adaptive immune response, and plays an important role in the development of autoimmune disease and antitumor activity. It has been reported that IL-21 is produced by CD4(+) T cells and NKT cells. However, the differentiation of IL-21-producing CD4(+) T cel...

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Библиографические подробности
Главные авторы: Yun Liu, Sifei Yu, Zitao Li, Jiangjun Ma, Yannan Zhang, Hui Wang, Binyan Yang, Changyou Wu
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2013-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC3669387?pdf=render
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