TGF-β Enhanced IL-21-Induced Differentiation of Human IL-21-Producing CD4(+) T Cells via Smad3

IL-21 has pleiotropic effects on innate and adaptive immune response, and plays an important role in the development of autoimmune disease and antitumor activity. It has been reported that IL-21 is produced by CD4(+) T cells and NKT cells. However, the differentiation of IL-21-producing CD4(+) T cel...

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Bibliographic Details
Main Authors: Liu, Yun, Yu, Sifei, Li, Zitao, Ma, Jiangjun, Zhang, Yannan, Wang, Hui, Yang, Binyan, Wu, Changyou
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669387/
https://ncbi.nlm.nih.gov/pubmed/23741351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064612
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