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Phosphorylation and dephosphorylation regulate APC/C(Cdh1) substrate degradation

The Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase activated by its G1 specific adaptor protein Cdh1 is a major regulator of the cell cycle. The APC/C(Cdh1) mediates degradation of dozens of proteins, however, the kinetics and requirements for their degradation are largely unknown. We...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Simpson-Lavy, Kobi J, Zenvirth, Drora, Brandeis, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825543/
https://ncbi.nlm.nih.gov/pubmed/26252546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1078036
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