Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinical problem in CML, and TKI therapy is much less eff...

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Veröffentlicht in:Blood
Hauptverfasser: Gu, Shengqing, Chan, Wayne W., Mohi, Golam, Rosenbaum, Joel, Sayad, Azin, Lu, Zhibin, Virtanen, Carl, Li, Shaoguang, Neel, Benjamin G., Van Etten, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825414/
https://ncbi.nlm.nih.gov/pubmed/26773044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-653006
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