Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array

Calpains are intracellular Ca(2+)-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis. Thus, it is critically important to determine th...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Shinkai-Ouchi, Fumiko, Koyama, Suguru, Ono, Yasuko, Hata, Shoji, Ojima, Koichi, Shindo, Mayumi, duVerle, David, Ueno, Mika, Kitamura, Fujiko, Doi, Naoko, Takigawa, Ichigaku, Mamitsuka, Hiroshi, Sorimachi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824854/
https://ncbi.nlm.nih.gov/pubmed/26796116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.053413
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