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A Simple Method for Enhancing the Bioorthogonality of Cyclooctyne Reagent
The cross-reactivity between some cyclooctynes and thiols limits the bioorthogonality of the strain-promoted azide–alkyne cycloaddition reaction. We show that a low concentration of β-mercaptoethanol significantly reduces the undesirable side reaction between bicyclononyne (BCN) and cysteine and whi...
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| Pubblicato in: | Chem Commun (Camb) |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824645/ https://ncbi.nlm.nih.gov/pubmed/27009873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc01321j |
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