Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors

To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency. Stability, small size, and efficacy of DARPins allowed the generation of M...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Hanauer, Jan RH, Gottschlich, Lisa, Riehl, Dennis, Rusch, Tillmann, Koch, Vivian, Friedrich, Katrin, Hutzler, Stefan, Prüfer, Steffen, Friedel, Thorsten, Hanschmann, Kay-Martin, Münch, Robert C, Jost, Christian, Plückthun, Andreas, Cichutek, Klaus, Buchholz, Christian J, Mühlebach, Michael D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824561/
https://ncbi.nlm.nih.gov/pubmed/27119117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.3
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