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Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis
Mutations in the PRSS1 gene encoding human cationic trypsinogen are associated with hereditary and sporadic chronic pancreatitis. High-penetrance PRSS1 mutations found in hereditary pancreatitis alter activation and/or degradation of cationic trypsinogen, thereby promoting intrapancreatic trypsinoge...
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| Publicado no: | Am J Physiol Gastrointest Liver Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824176/ https://ncbi.nlm.nih.gov/pubmed/26822915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00444.2015 |
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