Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Phosphorothioate (PS)-modified antisense oligonucleotides (ASOs) have been extensively investigated over the past three decades as pharmacological and therapeutic agents. One second generation ASO, Kynamro™, was recently approved by the FDA for the treatment of homozygous familial hypercholesterolem...

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Publicat a:Nucleic Acids Res
Autors principals: Miller, Colton M., Donner, Aaron J., Blank, Emma E., Egger, Andrew W., Kellar, Brianna M., Østergaard, Michael E., Seth, Punit P., Harris, Edward N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824115/
https://ncbi.nlm.nih.gov/pubmed/26908652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw112
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