Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination

In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences. These are recognised by helicase-nuclease complexes that process DNA ends for homologous recombination. Chi activates recombination by changing the biochemical properties of the helicase-nuclease, transforming it fr...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Gilhooly, Neville S., Carrasco, Carolina, Gollnick, Benjamin, Wilkinson, Martin, Wigley, Dale B., Moreno-Herrero, Fernando, Dillingham, Mark S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824097/
https://ncbi.nlm.nih.gov/pubmed/26762979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1543
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