Structural basis for translocation by AddAB helicase/nuclease and its arrest at Chi sites

In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence Chi(1,2) and is catalysed by either an AddAB or RecBCD-type helicase-nuclease (reviewed in refs 3, 4). These enzyme complexes unwind and digest the...

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Bibliographic Details
Main Authors: Krajewski, Wojciech W., Fu, Xin, Wilkinson, Martin, Cronin, Nora B., Dillingham, Mark S., Wigley, Dale B.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991583/
https://ncbi.nlm.nih.gov/pubmed/24670664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13037
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