Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR mutant Lung Cancer

Eitemau Tebyg

• EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors
  gan: Ercan, Dalia, et al.
  Cyhoeddwyd: (2015)
• Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
  gan: Zhou, Wenjun, et al.
  Cyhoeddwyd: (2009)
• Discovery of selective irreversible inhibitors for EGFR-T790M
  gan: Zhou, Wenjun, et al.
  Cyhoeddwyd: (2010)
• Reactivation of ERK Signaling causes resistance to EGFR kinase inhibitors
  gan: Ercan, Dalia, et al.
  Cyhoeddwyd: (2012)
• Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers co-driven by mutant EGFR containing T790M and MET
  gan: Xu, Lu, et al.
  Cyhoeddwyd: (2012)