EGF receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src

Aberrant activation of the EGF receptor (EGFR) contributes to many human cancers by activating the Ras-MAPK and other pathways. EGFR signaling is augmented by Src-family kinases, but the mechanism is poorly understood. Here, we show that human EGFR preferentially phosphorylates peptide substrates th...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Begley, Michael J, Yun, Cai-hong, Gewinner, Christina A, Asara, John M, Johnson, Jared L, Coyle, Anthony J, Eck, Michael J, Apostolou, Irina, Cantley, Lewis C
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824005/
https://ncbi.nlm.nih.gov/pubmed/26551075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3117
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