Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy

In renal cell carcinoma, transglutaminase 2 (TGase 2) crosslinks p53 in autophagosomes, resulting in p53 depletion and the tumor's evasion of apoptosis. Inhibition of TGase 2 stabilizes p53 and induces tumor cells to enter apoptosis. This study explored the mechanism of TGase 2-dependent p53 de...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kang, J H, Lee, J-S, Hong, D, Lee, S-H, Kim, N, Lee, W-K, Sung, T-W, Gong, Y-D, Kim, S-Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823929/
https://ncbi.nlm.nih.gov/pubmed/27031960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.14
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