Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Nicotinamide phosphoribosyltransferase (NAMPT) is a crucial enzyme in the biosynthesis of intracellular NAD(+). NAMPT inhibitors have potent anticancer activity in several preclinical models by depleting NAD(+) and ATP levels. Recently, we demonstrated that CD73 enables the utilization of extracellu...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Sociali, Giovanna, Raffaghello, Lizzia, Magnone, Mirko, Zamporlini, Federica, Emionite, Laura, Sturla, Laura, Bianchi, Giovanna, Vigliarolo, Tiziana, Nahimana, Aimable, Nencioni, Alessio, Raffaelli, Nadia, Bruzzone, Santina
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823084/
https://ncbi.nlm.nih.gov/pubmed/26658104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6502
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker