Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation

The Myc oncoprotein is tightly regulated at multiple levels including ubiquitin-mediated protein turnover. We recently demonstrated that inhibition of Cdk2-mediated phosphorylation of Myc at Ser-62 pharmacologically or through interferon (IFN)-γ-induced expression of p27(Kip1) (p27) repressed Myc�...

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Pubblicato in:Oncotarget
Autori principali: Bahram, Fuad, Hydbring, Per, Tronnersjö, Susanna, Zakaria, Siti Mariam, Frings, Oliver, Fahlén, Sara, Nilsson, Helén, Goodwin, Jacob, von der Lehr, Natalie, Su, Yingtao, Lüscher, Bernhard, Castell, Alina, Larsson, Lars-Gunnar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823075/
https://ncbi.nlm.nih.gov/pubmed/26701207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6693
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