Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and proliferation, and may contribute to the tropism of leukemia cells to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kashyap, Manoj K., Kumar, Deepak, Jones, Harrison, Amaya-Chanaga, Carlos I., Choi, Michael Y., Melo-Cardenas, Johanna, Ale-Ali, Amine, Kuhne, Michelle R., Sabbatini, Peter, Cohen, Lewis J., Shelat, Suresh G., Rassenti, Laura Z., Kipps, Thomas J., Cardarelli, Pina M., Castro, Januario E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823073/
https://ncbi.nlm.nih.gov/pubmed/26646452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6465
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