Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression

Bromodomain 4 (BRD4) is an epigenetic regulator that, when inhibited, has anti-cancer effects. In this study, we investigated whether BRD4 could be a target for treatment of human hepatocellular carcinoma (HCC). We show that BRD4 is over-expressed in HCC tissues. Suppression of BRD4, either by siRNA...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Gong-Quan, Guo, Wen-Zhi, Zhang, Yi, Seng, Jing-Jing, Zhang, Hua-Peng, Ma, Xiu-Xian, Zhang, Gong, Li, Jie, Yan, Bing, Tang, Hong-Wei, Li, Shan-Shan, Wang, Li-Dong, Zhang, Shui-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823048/
https://ncbi.nlm.nih.gov/pubmed/26575167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6275
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