EZH2 in normal hematopoiesis and hematological malignancies

Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 regulates normal hematopoietic stem cell self-renewal and differentiation. EZH2 also controls normal B cell differentiation. E...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Herviou, Laurie, Cavalli, Giacomo, Cartron, Guillaume, Klein, Bernard, Moreaux, Jérôme
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823035/
https://ncbi.nlm.nih.gov/pubmed/26497210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6198
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