Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice

IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immunoglobulins. IL6 also cooperates with IL21 to promote differentiation of CD4(+) T follicular helper cells (T(FH)). Elevated serum levels of IL6 correlate with disease flares in patients with systemic l...

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Veröffentlicht in:PLoS One
Hauptverfasser: Jain, Shweta, Park, Giljun, Sproule, Thomas J., Christianson, Gregory J., Leeth, Caroline M., Wang, Hongsheng, Roopenian, Derry C., Morse, Herbert C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822786/
https://ncbi.nlm.nih.gov/pubmed/27050763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153059
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