Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

Oncolytic viruses (OVs) are unique anticancer agents based on their pleotropic modes of action, which include, besides viral tumor cell lysis, activation of antitumor immunity. A panel of diverse viruses, often genetically engineered, has advanced to clinical investigation, including phase 3 studies...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Ungerechts, Guy, Bossow, Sascha, Leuchs, Barbara, Holm, Per S, Rommelaere, Jean, Coffey, Matt, Coffin, Rob, Bell, John, Nettelbeck, Dirk M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Review Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822647/
https://ncbi.nlm.nih.gov/pubmed/27088104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.18
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