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Spironolactone blocks Epstein–Barr virus production by inhibiting EBV SM protein function

Clinically available drugs active against Epstein–Barr virus (EBV) and other human herpesviruses are limited to those targeting viral DNA replication. To identify compounds directed against other steps in the viral life cycle, we searched for drugs active against the EBV SM protein, which is essenti...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Verma, Dinesh, Thompson, Jacob, Swaminathan, Sankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822607/
https://ncbi.nlm.nih.gov/pubmed/26976570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523686113
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