Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the inflammation t...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Ren, Qian, Ma, Min, Ishima, Tamaki, Morisseau, Christophe, Yang, Jun, Wagner, Karen M., Zhang, Ji-chun, Yang, Chun, Yao, Wei, Dong, Chao, Han, Mei, Hammock, Bruce D., Hashimoto, Kenji
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822604/
https://ncbi.nlm.nih.gov/pubmed/26976569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601532113
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