Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the inflammation t...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ren, Qian, Ma, Min, Ishima, Tamaki, Morisseau, Christophe, Yang, Jun, Wagner, Karen M., Zhang, Ji-chun, Yang, Chun, Yao, Wei, Dong, Chao, Han, Mei, Hammock, Bruce D., Hashimoto, Kenji
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822604/
https://ncbi.nlm.nih.gov/pubmed/26976569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601532113
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