Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the inflammation t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ren, Qian, Ma, Min, Ishima, Tamaki, Morisseau, Christophe, Yang, Jun, Wagner, Karen M., Zhang, Ji-chun, Yang, Chun, Yao, Wei, Dong, Chao, Han, Mei, Hammock, Bruce D., Hashimoto, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822604/
https://ncbi.nlm.nih.gov/pubmed/26976569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601532113
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