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Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

During the mitochondrial permeability transition, a large channel in the inner mitochondrial membrane opens, leading to the loss of multiple mitochondrial solutes and cell death. Key triggers include excessive reactive oxygen species and mitochondrial calcium overload, factors implicated in neuronal...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Chaudhuri, Dipayan, Artiga, Daniel J., Abiria, Sunday A., Clapham, David E.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822583/
https://ncbi.nlm.nih.gov/pubmed/26976564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602264113
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