Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy

The mitochondrial Ca(2+) uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca(2+) influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca(2+) uptake is fundamental for cardiomyocytes to adapt to ei...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zaglia, Tania, Ceriotti, Paola, Campo, Antonio, Borile, Giulia, Armani, Andrea, Carullo, Pierluigi, Prando, Valentina, Coppini, Raffaele, Vida, Vladimiro, Stølen, Tomas O., Ulrik, Wisløff, Cerbai, Elisabetta, Stellin, Giovanni, Faggian, Giuseppe, De Stefani, Diego, Sandri, Marco, Rizzuto, Rosario, Di Lisa, Fabio, Pozzan, Tullio, Catalucci, Daniele, Mongillo, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664523/
https://ncbi.nlm.nih.gov/pubmed/29073097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708772114
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