BRCA2 regulates DMC1-mediated recombination through the BRC repeats

In somatic cells, BRCA2 is needed for RAD51-mediated homologous recombination. The meiosis-specific DNA strand exchange protein, DMC1, promotes the formation of DNA strand invasion products (joint molecules) between homologous molecules in a fashion similar to RAD51. BRCA2 interacts directly with bo...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Martinez, Juan S., von Nicolai, Catharina, Kim, Taeho, Ehlén, Åsa, Mazin, Alexander V., Kowalczykowski, Stephen C., Carreira, Aura
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822569/
https://ncbi.nlm.nih.gov/pubmed/26976601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601691113
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