A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the associat...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Delahaye-Sourdeix, Manon, Anantharaman, Devasena, Timofeeva, Maria N., Gaborieau, Valérie, Chabrier, Amélie, Vallée, Maxime P., Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V., Barzan, Luigi, Canova, Cristina, Thakker, Nalin S., Conway, David I., Znaor, Ariana, Healy, Claire M., Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Fernández Garrote, Leticia, Polesel, Jerry, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A., Mahimkar, Manoj B., Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, McKay, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822523/
https://ncbi.nlm.nih.gov/pubmed/25838448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv037
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