Can a genotype for lactase persistence be used as a tool to assess the relationship between renal cell carcinoma and milk drinking? Pitfalls in the application of Mendelian randomization

BACKGROUND: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies including that involved here. Whether this represents causal association or whether it is the result of confounding or bias is unclear. We aimed to assess the potential for gen...

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Detalhes bibliográficos
Main Authors: Timpson, Nic, Brennan, Paul, Gaborieau, Valérie, Moore, Lee, Zaridze, David, Matveev, Vsevolod, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Chow, Wong-Ho, Rothman, Nathaniel, Boffetta, Paolo, Harbord, Roger, Davey Smith, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141143/
https://ncbi.nlm.nih.gov/pubmed/20447925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-09-1019
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