A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the associat...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Natl Cancer Inst
Prif Awduron: Delahaye-Sourdeix, Manon, Anantharaman, Devasena, Timofeeva, Maria N., Gaborieau, Valérie, Chabrier, Amélie, Vallée, Maxime P., Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V., Barzan, Luigi, Canova, Cristina, Thakker, Nalin S., Conway, David I., Znaor, Ariana, Healy, Claire M., Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Fernández Garrote, Leticia, Polesel, Jerry, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A., Mahimkar, Manoj B., Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, McKay, James D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Brief Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822523/
https://ncbi.nlm.nih.gov/pubmed/25838448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv037
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